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Onset • Visible improvements—such as enhanced radiance and hydration—typically begin within 2 weeks, with progressive changes over 4–6 weeks as collagen synthesis is supported. Longevity • Benefits such as improved texture, elasticity, and reduced fine lines can last up to 6 months, depending on patient age, lifestyle, and skin condition. Recommended Protocol • Many practitioners advise 1–3 sessions spaced 2–4 weeks apart for optimal results. • Maintenance sessions may be performed periodically to preserve skin quality over time. Safety & Downtime • Expected downtime is minimal; mild redness, swelling, or tenderness may occur. • As with all injectables, administration must follow strict aseptic and anatomical safety protocols.