Effectiveness of STYLAGE L Lidocaine for Nasolabial Folds

The NICE Study, a randomized, double-blind, split-face controlled trial, evaluated STYLAGE® L Lidocaine against Juvéderm® ULTRA 3 for the correction of moderate to severe nasolabial folds. The primary endpoint was the mean change in the Wrinkle Severity Rating Scale (WSRS) from baseline to six months post-treatment.

• The study demonstrated non-inferiority of STYLAGE® L Lidocaine to Juvéderm® ULTRA 3, with the upper limit of the 95% confidence interval for the difference in WSRS change being less than 0.5. This indicates that STYLAGE® L Lidocaine offers comparable wrinkle reduction.
• NLF depth was similarly reduced by both treatments at one month, with a decrease of approximately 0.049 mm for both STYLAGE® L Lidocaine and Juvéderm® ULTRA 3, and this reduction was generally maintained throughout the study period.
• Both evaluators and subjects reported improvements in NLFs, with a high percentage of responders across both treatment groups as assessed by the Global Aesthetic Improvement Scale (GAIS).
• Subject satisfaction was reported as high, and both devices were well tolerated by participants.

Clinical Considerations and Product Comparison

• The NICE Study's findings support the use of STYLAGE® L Lidocaine as a viable option for nasolabial fold correction, offering results comparable to established fillers like Juvéderm® ULTRA 3.
• Both STYLAGE® and Juvéderm® are hyaluronic acid-based fillers, and their efficacy in treating nasolabial folds highlights the versatility of HA fillers in addressing signs of aging.
• The inclusion of lidocaine in STYLAGE® L Lidocaine contributes to patient comfort during the injection procedure, a factor noted with low pain ratings in the study.

Safety and Limitations

The NICE Study indicated that both STYLAGE® L Lidocaine and Juvéderm® ULTRA 3 were well tolerated, with low pain ratings during injection. The long-term safety profile up to 12 months suggests comparable safety between the two products. As with any injectable treatment, potential side effects may include temporary redness, swelling, or bruising at the injection site. A detailed discussion with a healthcare provider is recommended to understand the full safety profile and any specific contraindications.