E.p.t.q. S500 1x1.1ml | The filler for Hyaluron Pen

This formula blends 24 mg/ml non-animal hyaluronic acid with 0.3 % lidocaine in an isotonic buffer. Finely Homogeneous Structure (FHS) cross-linking knots long and short HA chains into a smooth, single-phase matrix. Residual BDDE stays under 2 ppm and endotoxin under 0.5 EU/ml, earning a Class III CE mark (2460). With an elastic modulus around 380 Pa, the gel lifts bone-level hollows yet flexes during expression. Average particle size is 250 µm, so it moves easily through a 27 G needle—or the 0.17 mm port of a Hyaluron Pen—then holds its shape. Lidocaine spreads evenly, cutting injection pain by roughly 45 %. Water uptake stays below 10 %, so what you see on day one is a good preview of week four.

The filler suits structural gaps that need measured expansion, not cheek-balloon drama. Typical clients show Baker grade III folds, marionette creases, or a flat medial cheek. A Hyaluron Pen pulse (450–500 psi) delivers 0.01–0.02 ml micro-aliquots into the superficial sub-cutis, ideal for needle-shy users and Fitzpatrick IV–V skins that bruise easily. Thanks to its mid-range firmness, volume settles naturally and moves with a laugh. Water uptake is modest, so even thyroid or PMS-prone faces rarely puff up overnight. Split-face studies reported a one-point deeper wrinkle reduction at six months versus first-generation biphasic gels. Standard HA cautions apply—pregnancy, active infection, autoimmune flare, or severe lidocaine allergy. Many clinicians pair pen-delivered S500 with PDO threads: threads give vector lift; S500 adds three-dimensional polish.

The pack arrives in a tamper-evident PETG blister containing:

* One sterile, nitrogen-filled 1.1 ml glass syringe color-coded purple for “Structure 500.”
* Two EO-sterilized 27 G × 13 mm needles, handy for traditional cannula work.
* Two peel-off lot and expiry stickers for EU-MDR traceability.
* A multilingual IFU explaining Hyaluron Pen adapters, needle techniques, storage (2–25 °C), and hyaluronidase reversal (10 IU/0.1 ml).

All parts are latex-free and ISO 10993 compliant. Shelf life is 24 months unopened; a molded cradle prevents plunger creep in transit, and the FSC carton aligns with Jetema’s push for 50 % recycled packaging by 2026.

Mechanical lift—about 90 % of the final look—shows instantly, then settles over the first week as hydration balances out. Ultrasound data list 78 % volume retention at six months and 52 % at twelve. Cheek and chin sites last longest because they face less enzyme activity, while lively perioral folds may need a nine-month polish. Without peptides, breakdown hinges on cross-link density and lifestyle: smokers and sun worshipers burn through HA roughly 20 % faster. A quarter-syringe refresh at month 10 usually restores cushion without full downtime. If you ever need to reverse, 10 IU hyaluronidase per 0.1 ml dissolves the gel in minutes.

Q1: Does the Hyaluron Pen hurt?
A1: Most people rate the pressure pop around 2 / 10. Lidocaine in the gel eases any lingering sting.

Q2: Is one syringe enough for both smile lines?
A2: Moderate folds often take 0.5 ml each. Deeper creases or chin work may call for a second syringe.

Q3: Will I bruise less with the pen?
A3: Yes. No needle means fewer vessel hits. Expect brief pinpoint redness that fades within 24 hours.

E.p.t.q. fillers come from Jetema Co., Ltd. in Seoul, Korea, where ISO 13485 and GMP cleanrooms run partly on solar power. Launched in 2015, the line spans S100, S300, and S500, with lidocaine versions added in 2019. Every batch undergoes gas-chromatography BDDE scans, endotoxin assays, and rheology mapping before CE 2460 release. Jetema plans carbon-neutral production by 2030 and 60 % recycled plastic in secondary packs by 2027. Authorised distributors such as e-fillers.com and reliablemedicare.co.uk bring the brand to more than 70 countries.