Innoaesthetics Hyaluronidase 100 IU/ml 4 x 5ml

Each sterile 5 ml vial delivers 500 IU of highly purified, recombinant human hyaluronidase in a neutral pH buffer. The enzyme comes from Pichia pastoris yeast, so there are no animal proteins to trigger IgE reactions. Activity checks confirm 100 IU per millilitre at release and after stress tests. Mannitol and trehalose protect the protein during shipping. Endotoxin stays under 0.5 EU/ml and residual host-cell DNA under 10 pg/mg, all within Class III CE limits. Once injected, the enzyme clips the β-1,4 links in cross-linked and native HA, breaking the gel into tiny fragments the lymphatic system can clear. A 50-minute half-life at body temperature gives you time to work while limiting spread to distant tissue.

Use this hyaluronidase whenever HA filler needs to go—overfilled lips, blue-tinged tear troughs, or lumpy self-injections. In emergencies, inject 30–75 IU per cm² every hour until capillary refill returns and skin color looks healthy. For planned corrections, typical doses run 10 IU per 0.1 ml of lip filler, 5 IU per 0.1 ml in thin under-eye skin, and up to 30 IU per 0.1 ml for firm jawline gels. Beyond cosmetics, the enzyme softens HA-rich hypertrophic scars and speeds the drain of stubborn fluid pockets. Skip use in people allergic to bee venom (similar protein structure), those with active infection at the site, or during pregnancy unless absolutely necessary. For multi-allergic patients, a 15-minute forearm test dose adds safety.

The carton holds four type I glass vials with chlorobutyl stoppers and flip-off caps, plus two peel-off lot and expiry labels for charts. The IFU explains:

* Storage at 2–8 °C (stable 24 h at or below 25 °C once opened)
* Dilution tips if mixing with lidocaine or buffered saline
* Maximum 0.5 ml per single injection point
* A step-by-step emergency occlusion plan

Needles are not supplied; choose a 30 G for delicate eye work or a 27 G for larger areas. Shelf life is 24 months unopened; discard any leftover solution 24 hours after puncture.

Swelling starts to drop within minutes as the enzyme breaks the HA network. Ultrasound studies report more than 80 % filler clearance at 24 hours and complete removal by day 7. Your own skin HA bounces back within 48 hours, so you can safely reinject new filler after two weeks. When used on scars, tissue feels noticeably softer by week 4 and stays pliable for at least a year. The enzyme clears from the body in about 72 hours, so repeat doses do not build up.

Q1: Will it erase my natural hyaluronic acid forever?
A1: No. Your skin replenishes its own HA within two days, while the filler fragments exit through lymphatics.

Q2: Is the injection painful?
A2: Discomfort is mild. Many injectors draw up the dose with 0.1–0.2 ml preservative-free lidocaine for extra comfort.

Q3: How long should I wait before adding new filler?
A3: Two weeks. That window lets the enzyme finish its work and any swelling settle, giving you a clean slate.

Innoaesthetics produces and fills this hyaluronidase in GMP, ISO 13485 facilities in Barcelona. Every batch passes HPLC purity checks, sterility culture, and heat-stress tests before earning the CE mark. The company is pushing toward carbon-neutral manufacturing by 2030 and 60 % recycled packaging by 2026. This enzyme range complements Innoaesthetics’ peels, mesotherapy, and boosters, giving clinics a full toolkit for safe, flexible aesthetic care.