Profhilo H+L 1x 2,0 ml

Profhilo H+L contains 64 mg of hyaluronic acid per 2 ml syringe, split evenly between high- and low-molecular-weight HA for around 32 mg/ml each. Unlike traditional fillers with chemical cross-linkers, Profhilo uses a patented thermal process to fuse these into stable hybrid complexes without added chemicals.

This design delivers Hydrolift Action—a combination of deep hydration and gentle lift. The gel spreads easily through tissue, attracting water and promoting collagen and elastin production for smoother, firmer skin.

Because it is BDDE-free, Profhilo has low viscosity and high cohesivity, making it easy to inject with minimal force. It disperses widely from each injection point, supporting the five-point BAP technique while lowering risks of nodules.

Profhilo H+L is designed for treating skin laxity rather than adding volume. It’s ideal for patients aged 30–65 with early sagging or thinning skin on the face, neck, or décolletage.

It excels in delicate areas where thicker fillers can look lumpy, such as temples, fine lip lines, and smokers’ lines. Profhilo hydrates deeply, improves dermal density, and stimulates fibroblast activity, leading to firmer, more elastic skin.

It can also be combined with light fillers or polynucleotides for even greater aesthetic benefit. Compared with lasers or radiofrequency devices, Profhilo offers minimal downtime and only five micro-injections per side.

Contraindications are the same as other HA injectables: pregnancy, active skin infections, autoimmune conditions, or known HA allergies.

Each Profhilo H+L kit includes:

1 x 2 ml pre-filled glass syringe with batch and CE markings

2 x 29 G 13 mm sterile thin-wall needles for smooth delivery

2 traceability labels for patient records

Instructions for Use leaflet with guidance on the BAP injection technique and aftercare

The syringe uses medical-grade materials to maintain HA quality. Packaging includes oxygen absorbers to protect the product during storage. Shelf life is three years at 2–25 °C.

Profhilo’s results typically appear within 5–7 days, with improved skin hydration and radiance. Clinical studies show significant hydration increases by week four, remaining elevated for months. A standard treatment plan involves two sessions one month apart, with effects lasting 6–9 months. A maintenance booster at nine months can extend benefits up to 12 months in patients with less sun damage. Skin quality gains include smoother texture, better elasticity, and subtle lifting without adding bulk. Repeat treatments have not been linked to granulomas or allergic reactions thanks to its BDDE-free formula.

Q1: How many sessions are needed?
A1: Two sessions four weeks apart using the five-point BAP technique, with maintenance recommended every 6–9 months.

Q2: Does it replace volumizing fillers?
A2: No. Profhilo improves hydration and firmness but adds minimal volume. It can be layered under light fillers for combined results.

Q3: Is it painful?
A3: Most patients report mild stinging. The low-viscosity gel passes easily through fine needles, with only five injection points per side needed.

Q4: Is Profhilo FDA-approved?
A4: It holds a CE Class III certificate for use in Europe but is not FDA-cleared for the U.S.

Profhilo H+L

Profhilo H+L is produced by IBSA Derma, the dermatology division of Institut Biochimique SA—a Swiss-Italian pharma company with decades of experience in HA production.

IBSA pioneered thermal hybrid HA technology in 2013. Their facilities meet ISO 13485 and ISO 14001 standards, using 100% green electricity and advanced sustainability practices.

The company also supports academic research and healthcare education through dedicated foundations and initiatives, reflecting its commitment to innovation and social responsibility.