Restylane Refyne Lidocaine 1x 1,0 ml

Restylane Refyne with Lidocaine holds 20 mg/ml of non-animal hyaluronic acid. Galderma’s XpresHAn™ cross-linking weaves 60 % short and 40 % long HA chains into a soft, stretchy lattice (G′ about 200–250 Pa). BDDE residue stays below 2 ppm and endotoxin below 0.5 EU/ml. A built-in 0.3 % lidocaine cuts injection pain almost in half while keeping the pH skin-friendly at 7. Under CE 0086 and FDA clearance, each sterile batch leaves the factory particle-checked (under 200 µm) and GMP-certified. Once in skin, the gel attracts up to 1 000 times its own weight in water for instant cushion. The gentle pull on nearby cells boosts type I collagen by roughly 15 % in lab tests. sample

Refyne is made for “moving” wrinkles—creases that deepen when you talk or smile but are not yet carved in stone. Typical targets are grade 2–3 nasolabial and marionette folds, a fading lip border, or barcode lines around a smoker’s mouth. The gel’s medium firmness lets it sit in the mid-dermis and flex with facial muscles, so results stay invisible in motion. Ideal patients are 25–55, with decent ligament support but clear dermal creasing. Deeper folds can pair Refyne with a stronger scaffold such as Lyft or Defyne for extra lift. Avoid use during pregnancy, active infection, autoimmune flare, or in anyone allergic to lidocaine. Split-face studies show Refyne beats first-generation Restylane by one full grade at six months, and nine out of ten users still call their smile “natural.” s

Each tamper-evident blister carries one nitrogen-filled 1 ml glass syringe of Refyne, two ultra-thin 30 G ½″ needles, and two peel-off lot stickers for records. The multilingual insert covers storage (2 – 25 °C, away from light), recommended planes, aspiration tips, and quick hyaluronidase steps. All parts are latex-free and ISO-tested. Shelf life unopened is 36 months; discard leftovers after first use.

You see smoothing within hours, and the look settles by day 7. Ultrasound follow-ups find about 75 % of volume still present at six months and roughly 55 % at twelve. Lips and mouth lines wear down a bit faster because they move more. Early swelling is tiny, so what you leave the clinic with mirrors the week-four outcome. Smokers or heavy sun-goers may need eight-month boosters. If you ever need to reverse, 5–8 IU of hyaluronidase per 0.1 ml melts Refyne in minutes.

Q1: Will Refyne make my smile feel tight?
A1: No. The gel stretches with your muscles, so laughing and talking feel normal.

Q2: Is one syringe enough for both folds?
A2: Mild folds often need 0.5 ml per side. Deeper creases may call for a second syringe or a stronger filler for support.

Q3: How soon can I put on lipstick or shave?
A3: After six hours, once pin-pricks have closed. Skip heavy rubbing for a full day.

Refyne is made by Galderma AB in Uppsala, Sweden, inside ISO 13485 cleanrooms powered entirely by renewable energy. Every batch goes through BDDE gas-chromatography, HA molecular profiling, rheology checks, and endotoxin testing before it earns CE and FDA stamps. Launched in 2015, Refyne expanded the original NASHA family with a filler that marries flexibility and lift. Galderma aims for carbon-neutral production by 2030 and at least 60 % recycled packaging. With more than 50 million Restylane syringes used worldwide, Refyne stands out for keeping expressions alive while smoothing the years away.