PBSerum HA Total Corrector 25 μkat | 1500 IU/ml

PBSerum HA Total Corrector packs 25 µkat of ultra-pure, recombinant human hyaluronidase—about 1 500 IU after mixing. The enzyme is grown in *Pichia pastoris*, so there are no animal proteins to spark allergies. Each vial holds 4.5 mg of freeze-dried powder plus mannitol for stability. Add the supplied 5 ml of preservative-free saline and you get an isotonic, pH-neutral solution that spreads quickly under the skin.

Hyaluronidase snips the β-1,4 links inside both cross-linked filler and native HA, breaking them down into tiny fragments you clear in urine. Lab tests show a catalytic half-life of 38 minutes at body temperature—plenty of time to reach deep filler pockets before natural inhibitors shut it down. Because the enzyme is recombinant, BDDE is undetectable (< 0.1 ppm) and endotoxin stays under 0.5 EU/ml. The product carries a Class III CE 2797 mark but no FDA nod yet, so U.S. use is strictly off-label.
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This enzyme tackles three main jobs: rapid or planned HA-filler reversal, smoothing fibrous cellulite, and softening lumpy scars. Its 1 500 IU/ml punch means you need just one-tenth the volume compared with classic 150 IU bovine vials—great for delicate lips or tear troughs. Use it for overfilled lips, Tyndall blue shadows, stubborn cheek nodules, or early vascular-occlusion rescue. In cellulite, tiny 0.2 ml blebs spaced a centimetre apart every two weeks relax “orange-peel” dents without the bruising that deoxycholate can cause. Many dermatologists also micro-dose it into hypertrophic scars during microneedling sessions to speed remodelling. Skip treatment during pregnancy, active infection, or if the patient has a known bee-venom or enzyme allergy. s

A tamper-sealed carton holds five glass vials of freeze-dried enzyme capped with flip-off seals, plus five 5 ml ampoules of 0.9 % saline—no hunting for diluent. Each vial carries two peel-off lot stickers for perfect traceability, and the multilingual insert walks you through gentle swirling (never shake), dosing limits (0.5 ml per spot), and safe storage (2–25 °C, dry). Every batch is sterility-tested, potency-checked, and screened for host-cell DNA (< 10 pg/mg protein). Shelf life is two years unopened; once mixed, use within four hours—or refrigerate and toss after 24.

Filler lumps start softening in minutes and shrink by more than 80 % within a day, with full clearance in a week. For cellulite or scar work, ultrasound shows a 25 % drop in tissue stiffness at four weeks, and smoother skin lasts at least nine months. Because the enzyme breaks down in 48–72 hours, repeat sessions won’t pile up systemic activity, but most clinicians leave a two-week gap to judge progress and dodge overcorrection. In urgent vascular cases, a high-pulse plan—75 IU/cm² every hour for three hours—restores blood flow in over 95 % of reported incidents.

Q1: Will it erase my natural hyaluronic acid too?
Yes, briefly. Your own HA rebuilds within a day or two, while the filler fragments drain away, so normal fullness returns quickly.

Q2: Does it sting?
Not much—the saline is isotonic and the enzyme is pH-balanced. You can add a touch of lidocaine if a patient is sensitive.

Q3: Can I refill the area right after?
Better to wait two weeks. Residual enzyme can chew up new filler, and early swelling may hide true contours.

PBSerum professional enzymes come from Proteos Biotech S.L. in Murcia, Spain, where ISO 13485 cleanrooms run on renewable energy. A spin-off from the Spanish National Research Council, the firm checks every batch for purity, potency, and stability before the CE mark goes on. Sustainability moves include bio-ink cartons and recycled PET trays planned by 2026. With more than a million vials used in 40-plus countries, PBSerum’s recombinant hyaluronidase has earned a strong track record for fast, predictable, enzyme-driven corrections.