Restylane Defyne Lidocaine 1x 1,0 ml

Restylane Defyne Lidocaine packs 20 mg/ml of non-animal hyaluronic acid, cross-linked with Galderma’s OBT / XpresHAn process so the gel bends and stretches with your smile. A built-in 0.3 % lidocaine reduces injection pain by almost half. Lab checks keep BDDE residues below 2 ppm and endotoxin below 0.5 EU/ml, meeting strict EU class-III rules. The gel’s firmness (about 400 Pa) gives solid support yet stays flexible, and its 250 µm particles glide through a 27-gauge needle without drifting after placement. Once in the mid- to deep dermis—or right on the bone for chin work—the HA draws in water for instant lift. Over the next weeks, gentle pressure around the gel prompts new collagen, adding a bit more smoothness.

Restylane Defyne targets medium-to-deep folds and lower-face shape loss: nasolabial and marionette lines deeper than 3 mm, soft chins, or a fading jawline. Because the gel stretches as you talk or chew, it avoids the frozen look some stiffer fillers can cause. Inject deep dermis for wrinkles or right on the bone for contour. Best candidates are adults 30 – 65 with visible soft-tissue loss but decent skin tone. Split-face trials show Defyne beats the original Restylane by a full point on the wrinkle scale at six months, with most patients still improved at nine months. Skip treatment during pregnancy, active infections, autoimmune flares, or if you react badly to lidocaine.

• One sterile 1 ml glass syringe filled with Restylane Defyne Lidocaine, color-coded for quick ID
• Two single-use 27 G × ½″ needles, EO-sterilised and silicon-coated for smooth entry
• Two peel-off lot/expiry stickers for patient charts
• Multilingual instructions covering storage (2 – 25 °C), injection tips, and safe disposal

A snug blister cradle stops the plunger from creeping in transit. Everything is latex-free, ISO-tested, and marked with CE 0086 plus a Galderma hologram. Unopened shelf life: 36 months.

You see lift right away; the look settles over a week as the gel pulls in water. About 80 % of the volume remains at six months and 60 % at twelve. Jawlines and chins—areas that move less—can keep shape up to 15 months. Smokers or people in strong sun may need an 8-month top-up. Ultrasound at week 4 shows skin in the treated zone thickens by roughly 20 %, hinting at fresh collagen. If you ever need to reverse the filler, a quick shot of hyaluronidase dissolves it within minutes.

Q1: How soon can I wear makeup?
A1: After six hours—once the tiny needle spots are closed—light, breathable makeup is fine.

Q2: Will I feel bumps when I smile?
A2: Unlikely. Defyne bends with movement, and careful linear threading keeps ridges away.

Q3: What if I have dental work coming up?
A3: Schedule fillers at least two weeks after big dental visits so cheek pressure doesn’t shift the gel.

Galderma AB makes Restylane Defyne in Uppsala, Sweden, inside ISO 13485, GMP-certified cleanrooms run on renewable energy. The company launched NASHA fillers in 1996 and later created the flexible OBT / XpresHAn range, which includes Refyne and Defyne. Every batch undergoes BDDE, endotoxin, and rheology tests to keep performance steady. Galderma plans 60 % recycled plastic in syringes by 2027 and aims for carbon-neutral operations by 2030. Restylane products carry both CE and FDA clearances and are trusted in more than 100 countries.